PTSD TREATMENT

At Thaibogaine, we strive to provide top-notch health services, with a focus on personalized care that meets the unique needs of each patient. Our team of experienced professionals is dedicated to helping you achieve your health goals. Key Research Article from Stanford: Magnesium–Ibogaine Therapy in Veterans with Traumatic Brain Injuries (MISTIC Protocol)

• Study design: A prospective, open-label observational study conducted under the “Stanford Traumatic Injury to the CNS” protocol (MISTIC), involving 30 U.S. male Special Operations veterans who traveled to a clinic in Mexico (Ambio Life Sciences) for treatment with oral ibogaine plus magnesium—the latter intended to mitigate known cardiac risks associated with ibogaine (WIRED, Nature).
• Participants: All had histories of traumatic brain injury (TBI), repeated blast exposure, and clinically significant psychiatric and functional disabilities. At baseline, 23 met criteria for PTSD, 14 for anxiety, 15 for alcohol use disorder; 19 had suicidal ideation, and 7 had attempted suicide (Nature).
• Outcomes: 
  • Functional improvement: WHO Disability Assessment Scale scores dropped from an average of 30.2 (mild to moderate disability) at baseline to 19.9 immediately post-treatment and further to 5.1 (indicating minimal disability) at 1‑month follow-up (Nature).
  • PTSD, depression, and anxiety reductions: Significant and sustained symptom relief—PTSD symptoms reduced by ~88%, depression by ~87%, and anxiety by ~81% at 1‑month (Stanford Medicine).
• Neurocognitive gains: Veterans showed improvements in concentration, memory, information processing, and impulsivity. Neuropsychological testing confirmed enhancements without observed detriments (bbrfoundation.org).
• Safety: No serious or unexpected adverse events were reported. Only mild side effects such as nausea and headache occurred, and there were no instances of the cardiac arrhythmias associated with ibogaine when magnesium was co-administered (Nature).
• Caveats: As an open-label, uncontrolled study, it's limited in determining causality or excluding placebo effects—factors like the therapeutic setting, travel, patient expectations, and complementary modalities might contribute to outcomes (Nature, bbrfoundation.org, Stanford Medicine).

• A Stanford Medicine news release and coverage by outlets (e.g., Stanford News, Nature, Wired) highlight these impressive findings, emphasizing the dramatic symptom reductions, functional recovery, and cognitive improvements in severely affected veterans (Stanford News).
• A recent 2025 report even incorporated brain imaging data: increased theta rhythms linked to neuroplasticity, and reduced cortical complexity tied to stress response modulation—providing potential mechanistic insight into how ibogaine exerts therapeutic effects (MedPath).